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KMID : 0383820080650050405
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Tuberculosis and Respiratory Diseases
2008 Volume.65 No. 5 p.405 ~ p.409
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A Case of Churg-Strauss Syndrome with Multiple Tracheobronchial Mucosal Lesions
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Boo Sun-Jin
Lee Kwang-Ha
Ra Seung-Won
Jin Young-Joo
Park Gyung-Min
Hong Sang-Bum
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Abstract
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Churg-Strauss syndrome is a rare form of systemic necrotizing vasculitis that occurs exclusively in patients with
asthma, and is associated with blood and tissue eosinophilia. The classic pathology findings in the lung include a combination of eosinophilic pneumonia, granulomatous inflammation and necrotizing vasculitis. However, there are few reports of tracheobronchial mucosal lesions in Churg-Strauss syndrome. We report a case of Churg-Strauss syndrome with multiple tracheobronchial mucosal lesions in a 33-year-old man with a history of bronchial asthma and allergic rhinitis. He had been diagnosed with community acquired pneumonia at another hospital and was treated with antibiotics. However, the chest radiographic findings were aggravated and showed multifocal consolidations in the whole lung fields. He was transferred to the Asan Medical Center. Fiberoptic bronchoscopy revealed multiple nodular mucosal lesions of the trachea and bronchi. The histopathology of the mucosal lesions revealed necrotizing bronchial inflammation with eosinophilic infiltration. Video Assisted Thoracic Surgery was performed. The wedge resected lung tissue revealed chronic eosinophilic pneumonia that was consistent with Churg-Strauss syndrome. Methylprednisolone (1 mg/kg q 8 hr) was prescribed and his symptoms resolved gradually. The chest radiographic findings improved significantly, and a follow-up fiberoptic bronchoscopy performed eight days later showed that the tracheobronchial mucosal lesions had resolved. The patient was prescribed oral prednisolone for 20 months after discharge. Currently, the patient is not taking steroids and is being followed up.
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KEYWORD
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Churg-Strauss syndrome, Multiple tracheobronchial mucosal Lesions, Methylprednisolone
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